Conf. call with IDO 3-23-12
Friday, March 23, 2012, 2PM ET
Agenda/minutes for conference call with PO and IDO curators.
In attendance:
Back to Plant Disease Ontology main page.
Questions arising from reviews
Real data or problems in modeling disease
Is there an example/data set we can use as a test case?
access to ontology
Set up SVN site for draft on PO SVN?
Problematic terms from IDO
"The authors point out that the use of ‘clinical’ in OGMS / IDO and the definition of ‘symptom’ are problematic when building a plant disease ontology. This is (to me) one of the most interesting aspects of the paper. Have the authors tried to come up with more general definitions that would be universally applicable? Or is this not possible (why not)? It seems that the present structure works well for the plant ontology regardless, so I am not asking to revise the decision to build on OGMS / IDO. Rather I would be interested in a more detailed treatment of these problematic areas."
Examples of terms:
IDO:transition to clinical abnormality
IDO:subclinical infection
OGMS:symptom: A quality of a patient that is observed by the patient and is hypothesized by the patient to be a realization of a disease. (note that "patient" is not in the IDO)
Def. of symptom from Roberts and Boothroyd "Fundamentals of Plant Pathology": A visible expression by a suscept of a pathologic condition.
OGMS:disease: A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
Def. of disease from Roberts and Boothroyd: Harmful physiological processes caused by continuous irritation of a plant by a primary causal agen. It results in morbific cellular activity and is expressed in characteristic pathological responses called symptoms; continuous malfunctioning.
Def. of disease from Manners "Principals of Plant Pathology": harmful deviation from normal functioning of physiological processes. This definition allow malfunctions caused by non-living agencies such as mineral deficiency to be classed as diseases: such diseases are sometimes known as disorders...
Relations
"Several of the IDO-PD relations sound like they should be in IDO proper. Will they be communicated back? It also seems that these relations are “shortcut relations” for more complex constructs in BFO/RO. Have the authors explored making this connection explicit?"
has_causal_agent: This relation is used to indicate the causal agent of a disease or other stress. It has two subtypes: has_causal_biotic_agent and has_causal _abiotic_agent. In the IDO-PD, the domain is a plant infectious disease and the range is an organism that is bearer_of an infectious agent role.
primary/alternative_host_of: Two relations used to indicate whether a plant species is the primary or second-ary/alternative host of a disease, e.g., X. oryzae infected O. sativa primary_host_of X. oryzae infectious agent. The domain is an organism that is a subtype of Viridiplantae and is the bearer of a host role, and the range is an organism that is the bearer of an infectious agent role. Secondary hosts may be wild plant species that provide a place for the disease to survive when the crop host is not present or during a different part of the disease organism’s life cycle.
has_symptom: This relationship type is used to indicate the associated symptoms/traits that are evaluated to ascertain the manifestation of a stress or disease, e.g., rice bacterial leaf blight disease has_symptom leaf lesion.
found_in: This relationship is used to indicate the geograph-ical location of a host and/or pathogen species, e.g., X. oryzae found_in X. oryzae range. Instances of a disease or organisms also may have a found_in relation to an instance of a geographic region.
Trait Ontology
"While most ontologies mentioned are introduced a bit, the ‘trait ontology’ is only explained as “describing traits” (manuscript text) and dealing with “plant traits” (Table 1), which is not helpful to someone like me who is unsure what the scope of that ontology is."
Can PJ provide a one sentence description of the scope of the TO?
Other issues
Scope
Do we want to cover all green plants or just land plants?
Syncing with other ontologies
IDO
Multiple comments in IDO could cause problems with working with OE.
TO
The main issue will be from TO -- using IDOPD terms to logically define TO terms.
Other
Mireoting -- could Lindsay or Albert provide some help to RW on how to import terms using Mireot or other techniques.
How did you import terms from NCBI? Just re-use them?
Importing organisms
NCBItaxon ontology versus UBio id
What exactly do each of those stand for?
"A taxonomic classification of living organisms and associated artifacts for their controlled description within the context of databases."
From UBio: "NameBank is a biological name server. It stores and serves NameBankIDs via Life Science Identifiers, a persistent and distinct identifier. Each NameBank LSID returns a NameBank object which contains information about the NameBank record."
Neither of these resources say anywhere that their ids represent organisms of a particular class.
Wiki page
Should this be part of the PO wiki, should we create a separate wiki for IDO-PO?
Versioning and release policies
(Probably don't need to worry too much about these yet)
- OWL versus OBO
- Pre-reasoned version
